All Phenotypes Slc30a8<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc30a8^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4359863

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc30a8^tm1Lex/Slc30a8^tm1Lex	involves: 129S6/SvEvTac * C57BL/6	MGI:4359886

Allelic Composition	Slc30a8^tm1Lex/Slc30a8^tm1Lex
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc30a8^tm1Lex mutation (1 available); any Slc30a8 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:152629 )

N	• despite reduction in serum insulin levels, mice exhibit normal whole-body glucose metabolism

decreased insulin secretion ( J:152629 )

• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells

abnormal zinc homeostasis ( J:152629 )

• zinc content in islets is reduced compared to in wild-type cells

endocrine/exocrine glands

decreased insulin secretion ( J:152629 )

• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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