Slc30a8^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Slc30a8^tm1Lex
• Name: solute carrier family 30 (zinc transporter), member 8; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4359863
• Synonyms: ZnT-8^-, ZnT8 KO
• Gene: Slc30a8 Location: Chr15:52158949-52199194 bp, + strand Genetic Position: Chr15, 19.88 cM
• Alliance: Slc30a8^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152629
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exon 3 was replaced with an IRES-lacZ and neo cassette. (J:152629)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc30a8 Mutation: 22 strains or lines available

References

• Original: J:152629 Pound LD, et al., Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009 Aug 1;421(3):371-6
• All: 4 reference(s)