All Phenotypes Kif7<tm1.2Hui> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif7^tm1.2Hui
targeted mutation 1.2, Chi-chung Hui
MGI:4357956

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif7^tm1.2Hui/Kif7^tm1.2Hui	involves: 129S6/SvEvTac * CD-1	MGI:4357963
cx2	Gli2^tm1Alj/Gli2⁺ Kif7^tm1.2Hui/Kif7^tm1.2Hui	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * CD-1	MGI:4357967
cx3	Kif7^tm1.2Hui/Kif7^tm1.2Hui Smo^tm1Amc/Smo^tm1Amc	involves: 129S6/SvEvTac * 129X1/SvJ * CD-1	MGI:4357965

Allelic Composition	Kif7^tm1.2Hui/Kif7^tm1.2Hui
Genetic Background	involves: 129S6/SvEvTac * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^tm1.2Hui mutation (0 available); any Kif7 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:152259 )

• mice die at birth with several malformations

nervous system

abnormal neuron differentiation ( J:152259 )

• at E9.0, Nkx2-2+ and Olig2+ progenitor cells exhibit expansion and ectopic formation in the neural tubes compared to in wild-type mice

exencephaly ( J:152259 )

• at E14.5

skeleton

abnormal sternum morphology ( J:152259 )

abnormal xiphoid process morphology ( J:152259 )

• enlarged at E18.5

rib bifurcation ( J:152259 )

• at E18.5

rib fusion ( J:152259 )

• at E18.5

homeostasis/metabolism

edema ( J:152259 )

• at E14.5

limbs/digits/tail

polydactyly ( J:152259 )

• at E14.5

preaxial polydactyly ( J:152259 )

cellular

abnormal neuron differentiation ( J:152259 )

• at E9.0, Nkx2-2+ and Olig2+ progenitor cells exhibit expansion and ectopic formation in the neural tubes compared to in wild-type mice

Allelic Composition	Gli2^tm1Alj/Gli2⁺ Kif7^tm1.2Hui/Kif7^tm1.2Hui
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (173 available)
Kif7^tm1.2Hui mutation (0 available); any Kif7 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

embryo

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

Allelic Composition	Kif7^tm1.2Hui/Kif7^tm1.2Hui Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^tm1.2Hui mutation (0 available); any Kif7 mutation (40 available)
Smo^tm1Amc mutation (1 available); any Smo mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:152259 )

• at E9.0, the prospective spinal cord contains Oligo2+ progenitors and scattered Nkx2-2+ progenitor cells compared to in wild-type mice

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

exencephaly ( J:152259 )

absent neuronal precursor cells ( J:152259 )

• at E9.0, Shh+ and Foxa2+ progenitor cells are absent

embryo

embryo phenotype ( J:152259 )

N	• at E9.0, embryos are larger than Smo^tm1Amc homozygotes

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

cellular

abnormal neuron differentiation ( J:152259 )

• at E9.0, the prospective spinal cord contains Oligo2+ progenitors and scattered Nkx2-2+ progenitor cells compared to in wild-type mice

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