All Phenotypes Gck<Gls006> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gck^Gls006
glucose mutant 006
MGI:4357928

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^Gls006/Gck^Gls006	C3HeB/FeJ-Gck^Gls006	MGI:4357931
ht2	Gck^Gls006/Gck⁺	C3HeB/FeJ-Gck^Gls006	MGI:5446493

Allelic Composition	Gck^Gls006/Gck^Gls006
Genetic Background	C3HeB/FeJ-Gck^Gls006

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^Gls006 mutation (0 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:189544 )

N	• mice exhibit normal survival rates

homeostasis/metabolism

increased circulating glucose level ( J:189544 )

• 2-fold at birth

• in fasted and ad libitum fed mice

hyperglycemia ( J:137483 , J:189544 )

	• in 100% of mice (J:137483)
	• severe (J:189544)

decreased glucokinase activity ( J:189544 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:189544 )

• adult mice exhibit decreased total volumes and volume densities of islets and beta cells compared with wild-type mice

• however, neonates exhibit normal islets

abnormal pancreatic beta cell morphology ( J:189544 )

• adult mice exhibit decreased total volume and volume density beta cells compared with wild-type mice

• however, neonates exhibit normal beta cells

decreased pancreatic beta cell mass ( J:189544 )

• slightly

small pancreatic islets ( J:189544 )

growth/size/body

decreased body weight ( J:189544 )

• from P21 onward

Allelic Composition	Gck^Gls006/Gck⁺
Genetic Background	C3HeB/FeJ-Gck^Gls006

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^Gls006 mutation (0 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:189544 )

N	• mice exhibit normal insulin sensitivity

decreased insulin secretion ( J:189544 )

• in fasted mice at P30

increased circulating glucose level ( J:189544 )

• 1.3-fold at birth

• in fasted and ad libitum fed mice

• after glucose stimulation

hyperglycemia ( J:189544 )

• mild

decreased circulating insulin level ( J:189544 )

• in fasted mice at P30

impaired glucose tolerance ( J:189544 )

decreased glucokinase activity ( J:189544 )

• intermediate

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:189544 )

• slightly

small pancreatic islets ( J:189544 )

decreased insulin secretion ( J:189544 )

• in fasted mice at P30

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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