Gck^Gls006
Chemically induced Allele Detail

Summary

• Symbol: Gck^Gls006
• Name: glucokinase; glucose mutant 006
• MGI ID: MGI:4357928
• Synonyms: Gck^D217V
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^Gls006 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion in exon 6 results in the amino acid substitution of valine for aspartic acid at position 217 (D217V). This mutation is predicted to slightly increase overall glucokinase stability and favor torsion. (J:189544)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 59 strains or lines available

References

• Original: J:137483 Aigner B, et al., Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E232-40
• All: 2 reference(s)