Analysis Tools
mortality/aging
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• mice begin to die at 3 months of age with 50% of mice dead by 12 months of age
• death appears to be renal failure secondary to glomerulonephritis
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immune system
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• B cells have 2-fold or higher proliferation in response to numerous stimuli
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• mice have obvious splenomegaly and lymphadenopathy resulting from increased B cells
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• the percentage of B cells in the spleen is increased about 50% compared to controls
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• percentage of plasma cells found in spleen and lymph nodes is greatly increased
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• IgA levels are significantly increased
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• IgG1 levels are significantly increased
• antigen specific IgG1 levels are also increased relative to controls after immunization
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• IgG2a levels are significantly increased
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• IgG2b levels are significantly increased
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• IgM levels are increased almost 2-fold
• antigen specific IgM levels are also increased relative to controls after immunization
• antigen specific IgM responses are greater for T cell independent antigens than T cell dependent antigens
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• macrophages produce more IFN-alpha and IL-6 in response to numerous TLR ligands
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• mice have splenomegaly and lymphadenopathy resulting from increased B cells
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• dendritic cells have excessive cytokine production in response to numerous TLR ligands
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• plasmacytoid dendritic cells produce more IFN-alpha and IL-6 in response to A- or D-type CpG DNA than controls
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• there is increased IFN-alpha secretion by plasmacytoid dendritic cells in response to TLR engagement
• injection of a TLR7 ligand leads to increased levels of IFN-alpha 1 to 3 hours later compared to controls
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• macrophages and dendritic cells secrete increased amounts IL-6 in response to numerous TLR ligands
• injection of a TLR7 ligand leads to increased levels of IL-6 1 to 3 hours later compared to controls
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• macrophages and dendritic cells secrete increased amounts TNF in response to numerous TLR ligands
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• anti-nuclear antigen antibodies are found in the serum
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• anti-double stranded DNA antibodies are found in the serum
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• lymphocyte infiltrates are found in the liver and lungs
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• mice develop a lethal glomerulonephritis with deposition of IgG, IgM and complement components C3 and C1q in the glomeruli
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• lymphocyte infiltrates are found in the liver and lungs
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renal/urinary system
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• mice develop a lethal glomerulonephritis with deposition of IgG, IgM and complement components C3 and C1q in the glomeruli
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• deposition of IgG, IgM and complement components C3 and C1q in the glomeruli
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liver/biliary system
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• lymphocyte infiltrates are found in the liver and lungs
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hematopoietic system
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• B cells have 2-fold or higher proliferation in response to numerous stimuli
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• mice have obvious splenomegaly and lymphadenopathy resulting from increased B cells
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• the percentage of B cells in the spleen is increased about 50% compared to controls
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• percentage of plasma cells found in spleen and lymph nodes is greatly increased
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• IgA levels are significantly increased
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• IgG1 levels are significantly increased
• antigen specific IgG1 levels are also increased relative to controls after immunization
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• IgG2a levels are significantly increased
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• IgG2b levels are significantly increased
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• IgM levels are increased almost 2-fold
• antigen specific IgM levels are also increased relative to controls after immunization
• antigen specific IgM responses are greater for T cell independent antigens than T cell dependent antigens
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• macrophages produce more IFN-alpha and IL-6 in response to numerous TLR ligands
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respiratory system
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• lymphocyte infiltrates are found in the liver and lungs
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cellular
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• B cells have 2-fold or higher proliferation in response to numerous stimuli
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growth/size/body
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• mice have obvious splenomegaly and lymphadenopathy resulting from increased B cells
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