All Phenotypes Glyr1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Glyr1⁺
wild type
MGI:4355181

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Glyr1^em1(IMPC)Tcp/Glyr1⁺	C57BL/6N-Glyr1^em1(IMPC)Tcp/Tcp	MGI:6696752
cn2	Gata4^tm1.1Sad/Gata4⁺ Glyr1^em1Dsr/Glyr1⁺ Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	MGI:7279301

Allelic Composition	Glyr1^em1(IMPC)Tcp/Glyr1⁺
Genetic Background	C57BL/6N-Glyr1^em1(IMPC)Tcp/Tcp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glyr1^em1(IMPC)Tcp mutation (2 available); any Glyr1 mutation (30 available)

Data Sources

IMPC Data for Glyr1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - TCP

Allelic Composition	Gata4^tm1.1Sad/Gata4⁺ Glyr1^em1Dsr/Glyr1⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Glyr1^em1Dsr mutation (0 available); any Glyr1 mutation (30 available)
Tg(Tek-cre)1Ywa mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:322763 )

• VSD in all newborns, majority with atrio-ventricular septal defects (AVSDs)

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:322763 )

• mice born at below Mendelian ratios

postnatal lethality, incomplete penetrance ( J:322763 )

• 63% newborns die by age P1

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrioventricular septal defect		DOID:0050651	OMIM:606215 OMIM:614430 OMIM:614474	J:322763

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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