Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm2Ling mutation
(0 available);
any
Klf2 mutation
(12 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
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hematopoietic system
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• decrease in Ly6low blood and bone marrow monocytes as compared to controls
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immune system
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• decrease in Ly6low blood and bone marrow monocytes as compared to controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm2Ling mutation
(0 available);
any
Klf2 mutation
(12 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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hematopoietic system
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• single positive (SP) alpha-beta thymocytes express high levels of CXCR3
• CD8+ SP thymocytes express higher levels of CXCR3 than CD4+ SP thymocytes
• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes
• SP thymocytes secrete high levels of IL-4
• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus
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• mice have severe T cell lymphopenia
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• single positive thymocytes are increased
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• IgE levels are increased 33-fold
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• IgG1 levels are modestly increased
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immune system
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• single positive (SP) alpha-beta thymocytes express high levels of CXCR3
• CD8+ SP thymocytes express higher levels of CXCR3 than CD4+ SP thymocytes
• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes
• SP thymocytes secrete high levels of IL-4
• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus
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• mice have severe T cell lymphopenia
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• single positive thymocytes are increased
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• IgE levels are increased 33-fold
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• IgG1 levels are modestly increased
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• single-positive thymocytes produce about four-fold more IL-4 compared to controls
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