Phenotypes associated with this allele

• Allele Symbol: dde
• Allele Name: disproportionate dwarf and eye defect
• Allele ID: MGI:4354227
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	dde/dde	CByJ(Cg)-dde/GrsrJ	MGI:4441278

Genotype
MGI:4441278

hm1

• Allelic Composition: dde/dde
• Genetic Background: CByJ(Cg)-dde/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:159016 )

• the lifespan varies with some homozygotes dying shortly after weaning and others dying before 1 year of age

growth/size/body

thyroid gland cyst ( J:159016 )

• thyroid cysts are found in some homozygotes

disproportionate dwarf ( J:159016 )

• the femur and humerus are severely shortened, but the axial skeleton appears normal

skeleton

fused phalanges ( J:159016 )

• the hind feet have fused toes

vision/eye

abnormal retina morphology ( J:159016 )

• dysplasia of the retina is severe enough to present as numerous white lines in the retina

abnormal eye electrophysiology ( J:159016 )

• electroretinaogram assessment shows both abnormal rod and cone activity

abnormal cone electrophysiology ( J:159016 )

abnormal rod electrophysiology ( J:159016 )

behavior/neurological

abnormal maternal nurturing ( J:159016 )

♀ • females usually fail to provide adequate care to their offspring

reproductive system

abnormal male germ cell apoptosis ( J:159016 )

♂ • testis display apoptotic cells

reduced female fertility ( J:159016 )

♀

male infertility ( J:159016 )

♂

limbs/digits/tail

syndactyly ( J:159016 )

fused phalanges ( J:159016 )

• the hind feet have fused toes

respiratory system

emphysema ( J:159016 )

• emphysema may be found in some homozygotes

digestive/alimentary system

gastric polyps ( J:159016 )

• stomach polyp may be observed

endocrine/exocrine glands

thyroid gland cyst ( J:159016 )

• thyroid cysts are found in some homozygotes

cellular

abnormal male germ cell apoptosis ( J:159016 )

♂ • testis display apoptotic cells