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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tyr-BRAF*V600E)476Fgh
transgene insertion 476, Frank G Haluska
MGI:4354193
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(Tyr-BRAF*V600E)476Fgh/0 		involves: 129/Sv * C57BL/6J * CBA * SJL MGI:4354208
tg2
 		Tg(Tyr-BRAF*V600E)476Fgh/0 involves: C57BL/6J * CBA MGI:4354206


Genotype
MGI:4354208
cx1
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(Tyr-BRAF*V600E)476Fgh/0
Genetic
Background		 involves: 129/Sv * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (3 available); any Cdkn2a mutation (59 available)
Tg(Tyr-BRAF*V600E)476Fgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151455 )
• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice

neoplasm
increased melanoma incidence ( J:151455 )
• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)476Fgh

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
melanoma DOID:1909 J:151455




Genotype
MGI:4354206
tg2
Allelic
Composition		 Tg(Tyr-BRAF*V600E)476Fgh/0
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151455 )
• median survival is 595 days

neoplasm
increased malignant tumor incidence ( J:151455 )
• mice rarely develop melanomas

pigmentation
abnormal melanocyte morphology ( J:151455 )
• mice develop benign melanocyte hyperplasia showing large nests of epithelioid cells generally located in the deep dermis and subcutis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory