Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(Tyr-BRAF*V600E)470Fgh mutation
(0 available)
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mortality/aging
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• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice dying within days or weeks of developing hydrocephalus and paralysis
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neoplasm
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• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)470Fgh
• mice exhibit metastasis to the lung and lymph nodes
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behavior/neurological
nervous system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• median survival is 295 days due to development of melanoma in some mice and central nervous system involvement in others
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pigmentation
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• coat color ranging from normal to light
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• mice exhibit benign melanocytic hyperplasia similar to nevi with abundant spindle cells in the dermis and subcutaneous tissue, frequently termed Schwannian differentiation of melanocytes
• pigmented spindle cell proliferations are identified in the retro- and peri-bulbar areas of the eye the meninges, the temporal and parietal bones of the cranium, bone marrow cavity, and in the surrounding soft tissues
• benign proliferations can be locally aggressive
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• the skin of the ear pinnae and limbs as well as the dermis are hyperpigmented compared to in wild-type mice
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neoplasm
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• spindle cell tumors are variably pigmented with rare mitoses and exhibit Schwannian differentiation
• 10% of mice develop melanoma in the dermis, subcutis, and soft tissues with metastasis to the lymph nodes draining the region
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limbs/digits/tail
vision/eye
integument
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• coat color ranging from normal to light
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