Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr-BRAF*V600E)470Fgh
• Allele Name: transgene insertion 470, Frank G Haluska
• Allele ID: MGI:4354192
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-BRAF*V600E)470Fgh/0	involves: 129/Sv * C57BL/6J * CBA * SJL	MGI:4354207
tg2	Tg(Tyr-BRAF*V600E)470Fgh/0	involves: C57BL/6J * CBA	MGI:4354205

Genotype
MGI:4354207

cx1

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(Tyr-BRAF*V600E)470Fgh/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151455 )

• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice dying within days or weeks of developing hydrocephalus and paralysis

neoplasm

increased melanoma incidence ( J:151455 )

• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)470Fgh

• mice exhibit metastasis to the lung and lymph nodes

behavior/neurological

paralysis ( J:151455 )

nervous system

hydrocephaly ( J:151455 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:151455

Genotype
MGI:4354205

tg2

• Allelic Composition: Tg(Tyr-BRAF*V600E)470Fgh/0
• Genetic Background: involves: C57BL/6J * CBA

mortality/aging

premature death ( J:151455 )

• median survival is 295 days due to development of melanoma in some mice and central nervous system involvement in others

pigmentation

diluted coat color ( J:151455 )

• coat color ranging from normal to light

abnormal melanocyte morphology ( J:151455 )

• mice exhibit benign melanocytic hyperplasia similar to nevi with abundant spindle cells in the dermis and subcutaneous tissue, frequently termed Schwannian differentiation of melanocytes

• pigmented spindle cell proliferations are identified in the retro- and peri-bulbar areas of the eye the meninges, the temporal and parietal bones of the cranium, bone marrow cavity, and in the surrounding soft tissues

• benign proliferations can be locally aggressive

hyperpigmentation ( J:151455 )

• the skin of the ear pinnae and limbs as well as the dermis are hyperpigmented compared to in wild-type mice

neoplasm

increased malignant tumor incidence ( J:151455 )

• spindle cell tumors are variably pigmented with rare mitoses and exhibit Schwannian differentiation

• 10% of mice develop melanoma in the dermis, subcutis, and soft tissues with metastasis to the lymph nodes draining the region

limbs/digits/tail

thick tail ( J:151455 )

vision/eye

microphthalmia ( J:151455 )

• in some mice

integument

diluted coat color ( J:151455 )

• coat color ranging from normal to light