All Phenotypes Tg(Apoe-Fgf21)1Sakl MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Klb^tm1.2Sakl/Klb⁺ Tg(Apoe-Fgf21)1Sakl/0	involves: 129 * 129S4/SvJaeSor * C57BL/6	MGI:5446169
cx2	Klb^tm1.2Sakl/Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl/0	involves: 129 * 129S4/SvJaeSor * C57BL/6	MGI:5446170
tg3	Tg(Apoe-Fgf21)1Sakl/0	Not Specified	MGI:4354175

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:189018 )

• in mice fed a high fat diet

decreased circulating insulin level ( J:189018 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:189018 )

• in mice fed a high fat diet

decreased circulating cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased circulating free fatty acids level ( J:189018 )

• in mice fed a high fat diet

decreased circulating triglyceride level ( J:189018 )

• in mice fed a high fat diet

improved glucose tolerance ( J:189018 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:189018 )

• in mice fed a high fat diet

increased circulating adiponectin level ( J:189018 )

• in mice fed a high fat diet

decreased liver cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:189018 )

• in mice fed a high fat diet

skeleton

short tibia ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

adipose tissue

decreased percent body fat/body weight ( J:189018 )

• in mice fed standard chow or a high fat diet compared with Klb^tm1.2Sakl heterozygotes

growth/size/body

increased lean body mass ( J:189018 )

• in mice fed standard chow or a high fat diet compared with Klb^tm1.2Sakl heterozygotes

decreased body weight ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

decreased susceptibility to weight gain ( J:189018 )

• in mice fed a high fat diet

behavior/neurological

abnormal eating behavior ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

liver/biliary system

decreased liver cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:189018 )

• in mice fed a high fat diet

decreased liver weight ( J:189018 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:189018 )

• mice fed a high fat diet do not develop a pale liver and have less lipid droplets compared to Klb^tm1.2Sakl heterozygotes

limbs/digits/tail

short tibia ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

Allelic Composition	Klb^tm1.2Sakl/Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klb^tm1.2Sakl mutation (0 available); any Klb mutation (58 available)
Tg(Apoe-Fgf21)1Sakl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit changes in circulating triglyceride, cholesterol, leptin, adiponectin, insulin and glucose observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased circulating free fatty acids level ( J:189018 )

• in mice fed a high fat diet but not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

abnormal glucose homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit improved glucose tolerance and insulin sensitivity observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

growth/size/body

abnormal lean body mass ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased body weight ( J:189018 )

• not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

adipose tissue

abnormal percent body fat/body weight ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

behavior/neurological

abnormal food intake ( J:189018 )

• mice fail to exhibit an increase in food intake observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

limbs/digits/tail

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

liver/biliary system

abnormal liver morphology ( J:189018 )

• mice fed a high fat diet fail to exhibit a decrease in liver weight and hepatic triglyceride and cholesterol levels observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

skeleton

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

Allelic Composition	Tg(Apoe-Fgf21)1Sakl/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Apoe-Fgf21)1Sakl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased oxygen consumption ( J:150831 )

• hepatic oxygen consumption is increased in fasting mice compared with wild-type mice

• however, hepatic oxygen consumption under fed condition is normal

abnormal gluconeogenesis ( J:150831 )

• under fed conditions, liver gluconeogenesis is increased 60% compared to in similarly treated wild-type mice

• however, liver gluconeogenesis does not increase further under fasting conditions

increased liver glycogen level ( J:150831 )

• liver glycogen content increased 50% compared to in wild-type mice

liver/biliary system

increased liver glycogen level ( J:150831 )

• liver glycogen content increased 50% compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23