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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-fat-1)1Jxk
transgene insertion 1, Jing X Kang
MGI:4354100
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-fat-1)1Jxk/0
Tg(Pbsn-cre)4Prb/0 		involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 MGI:4847617


Genotype
MGI:4847617
cn1
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-fat-1)1Jxk/0
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(CAG-fat-1)1Jxk mutation (1 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased prostate gland weight ( J:124208 )
• mice fed a high-omega-6 diet exhibit significantly lower prostate weights than mice without Tg(CAG-fat-1)1Jxk

homeostasis/metabolism
abnormal lipid homeostasis ( J:124208 )
• mice fed a high-omega-6 diet exhibit a much lower omega-6/omega-3 ratio in the blood and prostate than mice without the Tg(CAG-fat-1)1Jxk transgene, indicating that fat-1 is able to convert most of the omega-6 polyunsaturated fatty acids to omega-3

reproductive system
decreased prostate gland weight ( J:124208 )
• mice fed a high-omega-6 diet exhibit significantly lower prostate weights than mice without Tg(CAG-fat-1)1Jxk




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory