Analysis Tools
nervous system
|
• hyperresponsiveness of cells in the nucleus tractus solitarii (marked by c-Fos expression) is lost in these mice under conditions of mild gastritis
|
|
Allele Symbol Allele Name Allele ID |
Asic3tm1Pho targeted mutation 1, Peter Holzer MGI:4353615 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• hyperresponsiveness of cells in the nucleus tractus solitarii (marked by c-Fos expression) is lost in these mice under conditions of mild gastritis
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• apoptosis in the outer and inner nuclear layer of the retina in mice over 8 months of age
|
|
• degradation of oscillatory potential as mice age suggests dysfunction of amacrine cells
• amacrine cells without nuclei are observed in mice at 16 months of age
• high amounts of apoptosis occur to retinal amacrine cells after 8 months of age
|
|
• ganglion cells in a degenerate state (i.e. lacking nuclei) are observed in the retinas of mice at 16 months of age
• high amounts of apoptosis occur to retinal ganglion cells after 8 months of age
|
|
• the inner segment layer less organized as the mice age
• some vacuolated areas also appear in this layer as the mice age
• massive cell death by 16 months of age leads to large vacuolated areas
|
|
• the outer segment layer in mice becomes thicker and less organized as the mice age
• some vacuolated areas appear in this layer as the mice age
|
|
• the inner nuclear layer becomes thinner by 16 months of age
|
|
• the outer nuclear layer becomes disorganized as mice age
|
|
• the outer nuclear layer becomes thinner by 16 months of age
|
|
• the outer plexiform layer becomes thinner by 16 months of age
|
|
• oscillatory potential is impaired in mice as they age
|
|
• 3-month old mice have enhanced scoptic a-wave with a maximum amplitude difference of 19.3%
• a-wave amplitudes decrease with age so that maximum amplitude is decreased by 18%, 40%, and 69% of controls at 8, 12, and 16 months of age, respectively
• genotype effect on b-wave amplitudes is attributed to rod cell defects because no differences are seen under photobleaching conditions
• 3-month old mice have enhanced scoptic b-wave with a maximum amplitude difference of 17.6%
• b-wave amplitudes decrease with age so that maximum amplitude is decreased by 21%, 32%, and 64% of controls at 8, 12, and 16 months of age, respectively
|
|
• degradation of oscillatory potential as mice age suggests dysfunction of amacrine cells
• amacrine cells without nuclei are observed in mice at 16 months of age
• high amounts of apoptosis occur to retinal amacrine cells after 8 months of age
|
|
• ganglion cells in a degenerate state (i.e. lacking nuclei) are observed in the retinas of mice at 16 months of age
• high amounts of apoptosis occur to retinal ganglion cells after 8 months of age
|
|
• the inner segment layer less organized as the mice age
• some vacuolated areas also appear in this layer as the mice age
• massive cell death by 16 months of age leads to large vacuolated areas
|
|
• the outer segment layer in mice becomes thicker and less organized as the mice age
• some vacuolated areas appear in this layer as the mice age
|
|
• apoptosis in the outer and inner nuclear layer of the retina in mice over 8 months of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||