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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grm5tm1.1Kksz
targeted mutation 1.1, Karen K Szumlinski
MGI:4353518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Grm5tm1.1Kksz/Grm5tm1.1Kksz involves: 129S1/Sv * 129X1/SvJ MGI:5461826
hm2
Grm5tm1.1Kksz/Grm5tm1.1Kksz involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4353623


Genotype
MGI:5461826
hm1
Allelic
Composition
Grm5tm1.1Kksz/Grm5tm1.1Kksz
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1.1Kksz mutation (0 available); any Grm5 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• formalin-treated mice exhibit greater response to pain during the second phase, but not the first phase, compared with wild-type mice




Genotype
MGI:4353623
hm2
Allelic
Composition
Grm5tm1.1Kksz/Grm5tm1.1Kksz
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1.1Kksz mutation (0 available); any Grm5 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• using a scheduled high alcohol consumption model, mice exhibit a 75% reduction in binge alcohol consumption compared with wild-type mice
• however, no difference in alcohol consumption was observed in a model of voluntary alcohol preference drinking or when mice are pre-treated via the intra-nucleus accumbens with MPEP or wortmannin





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory