Grm5^tm1.1Kksz
Targeted Allele Detail

Summary

• Symbol: Grm5^tm1.1Kksz
• Name: glutamate receptor, metabotropic 5; targeted mutation 1.1, Karen K Szumlinski
• MGI ID: MGI:4353518
• Synonyms: Grm5^R, mGluR5^F1128R
• Gene: Grm5 Location: Chr7:87233376-87784115 bp, + strand Genetic Position: Chr7, 49.01 cM
• Alliance: Grm5^tm1.1Kksz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151084
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The open reading frame was replaced with one containing two point mutations (TTC to CGC) in exon 8. These mutations result in an amino acid substitution of arginine for phenylalanine at position 1128 (F1128R). An upstream floxed neo was removed by germ line, cre mediated recombination. This mutation is expected to reduce Homer binding. (J:151084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm5 Mutation: 75 strains or lines available

References

• Original: J:151084 Cozzoli DK, et al., Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci. 2009 Jul 8;29(27):8655-68
• All: 5 reference(s)