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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themis5AT161
5AT161
MGI:4353412
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themis5AT161/Themis5AT161 involves: C57BL/6 MGI:4353422
cx2
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161 		involves: 129S/SvEv * C57BL/6 MGI:4353423
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themis5AT161/Themis5AT161 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4353424


Genotype
MGI:4353422
hm1
Allelic
Composition		 Themis5AT161/Themis5AT161
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis5AT161 mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:151076 )
• there is a lower percentage of CD44loCD4+ T cells in the blood than in controls
• nave CD4 T cell population is only 12% that of controls
decreased CD8-positive, alpha-beta T cell number ( J:151076 )
• the nave CD8 T cell population is 30% of that in controls
decreased regulatory T cell number ( J:151076 )
• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population
decreased single-positive T cell number ( J:151076 )
• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls
• significant loss in the immature CD4+ subset in the thymus

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151076 )
• there is a lower percentage of CD44loCD4+ T cells in the blood than in controls
• nave CD4 T cell population is only 12% that of controls
decreased CD8-positive, alpha-beta T cell number ( J:151076 )
• the nave CD8 T cell population is 30% of that in controls
decreased regulatory T cell number ( J:151076 )
• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population
decreased single-positive T cell number ( J:151076 )
• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls
• significant loss in the immature CD4+ subset in the thymus




Genotype
MGI:4353423
cx2
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (3 available)
Themis5AT161 mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected

immune system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected




Genotype
MGI:4353424
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themis5AT161/Themis5AT161
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Themis5AT161 mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased single-positive T cell number ( J:151076 )
• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls

immune system
decreased single-positive T cell number ( J:151076 )
• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory