Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1.2Fan mutation
(0 available);
any
Pax7 mutation
(39 available)
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muscle
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• mice exhibit severe muscle regeneration defect with few regenerating myofibers and accumulation of fibrosis unlike in wild-type mice
• the few regenerating myofibers express Pax7
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3tm1.1Sjc mutation
(0 available);
any
Pax3 mutation
(50 available)
Pax7tm1.2Fan mutation
(0 available);
any
Pax7 mutation
(39 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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muscle
N |
• following tamoxifen-treatment, muscle regeneration is normal as are the proliferative and myogenic properties of adult myoblasts
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