All Phenotypes Tg(Pomc-FLP)1aBrn MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pomc-FLP)1aBrn
transgene insertion 1a, Anton Berns
MGI:4353096

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm1Brn/Rb1^tm1Brn Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353102
cn2	Rb1^tm1Brn/Rb1⁺ Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353103
tg3	Tg(Pomc-FLP)1aBrn/0	involves: FVB/N	MGI:4353100

Allelic Composition	Rb1^tm1Brn/Rb1^tm1Brn Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Brn mutation (1 available); any Rb1 mutation (107 available)
Tg(Pomc-FLP)1aBrn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:48860 )

• all mice die within 20 weeks (or 5 months)

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

nervous system

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

Allelic Composition	Rb1^tm1Brn/Rb1⁺ Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Brn mutation (1 available); any Rb1 mutation (107 available)
Tg(Pomc-FLP)1aBrn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

endocrine/exocrine glands

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

Allelic Composition	Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48860 )

• mice are healthy, fertile, and show no sign of disease

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23