Phenotypes associated with this allele

• Allele Symbol: Cers2^{Gt(S16-4B1)Sor}
• Allele Name: gene trap S16-4B1, Philippe Soriano
• Allele ID: MGI:4346044
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cers2^Gt(S16-4B1)Sor/Cers2^Gt(S16-4B1)Sor	involves: 129S4/SvJaeSor	MGI:4819185
hm2	Cers2^Gt(S16-4B1)Sor/Cers2^Gt(S16-4B1)Sor	involves: 129S4/SvJaeSor * C57BL/6	MGI:4421582

Genotype
MGI:4819185

hm1

• Allelic Composition: Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:179754 )

N • mice exhibit normal skin phenotype

Genotype
MGI:4421582

hm2

• Allelic Composition: Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Abnormal morphology of Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} trigeminal nerve axons

nervous system

abnormal brain white matter morphology ( J:156841 )

• at 9 months, multiple empty cysts are found in the white matter unlike in wild-type mice

abnormal hippocampal fimbria morphology ( J:156841 )

• smaller than in wild-type mice with ragged contours

abnormal cerebellar granule layer morphology ( J:156841 )

• at 9 months, multiple empty cysts are found in the internal granular layer unlike in wild-type mice

abnormal myelin sheath morphology ( J:156841 )

• 20% of axons in the trigeminal nerve exhibit inner surface defects of the myelin sheaths, including vesiculation and multifocal detachment of the inner myelin lamella, unlike in wild-type mice

• myelin stainability is progressively lost

abnormal trigeminal nerve morphology ( J:156841 )

• 20% of axons in the trigeminal nerve exhibit inner surface defects of the myelin sheaths, including vesiculation and multifocal detachment of the inner myelin lamella, unlike in wild-type mice

neoplasm

increased liver tumor incidence ( J:156841 )

• 1 mouse developed multiple liver adenomata

increased hepatocellular carcinoma incidence ( J:156841 )

• between 7 and 9 months, 2 of 3 mice develop hepatocellular carcinoma

• tumor cells are pale hepatocytes often filled with large lipid droplets

homeostasis/metabolism

abnormal lipid homeostasis ( J:156841 )

• fewer very long fatty acid ceramide species are detected in the brain, liver, and kidneys compared to in wild-type mice

liver/biliary system

increased liver tumor incidence ( J:156841 )

• 1 mouse developed multiple liver adenomata

increased hepatocellular carcinoma incidence ( J:156841 )

• between 7 and 9 months, 2 of 3 mice develop hepatocellular carcinoma

• tumor cells are pale hepatocytes often filled with large lipid droplets