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Allele Symbol Allele Name Allele ID |
Sec23bGt(AD0407)Wtsi gene trap AD0407, Wellcome Trust Sanger Institute MGI:4345347 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Small size of Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi neonates
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• similar to mice on an inbred C57BL/6J background
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• fail to suckle
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Small size of Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi neonates
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• generally die within 12 h of birth and none survive past 24 h
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• fail to suckle
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• degeneration of the nasal glands at E18.5
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• about 25% lower than littermate controls
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• degeneration of the nasal glands at E18.5
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• disruption of the structures of the serous and mucous acini of salivary glands
(J:186391)
• E-cadherin and beta-catenin are mislocalized in the salivary glands at E15.5
(J:237614)
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• serous acini contain grossly dilated ER and only a small percentage of acini contain secretory granules
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• mucous acini contain grossly dilated ER and lack secretory granules
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• degeneration of the salivary glands at E18.5
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• degeneration of gastric glands
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• accumulation of proamylase and other exocrine proteins in the ER
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• appears more opaque with a disorganized structure compared to controls
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• grape-like clusters are absent and there is no discernible islet structure
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• a few cells show distended ER at E13.5 and most cells have grossly distended ER at E16.5
(J:186391)
• E-cadherin (CDH1) is mislocalized to the cytoplasm of acinar cells at E11.5 and largely co-localizes with carboxylpeptidase A (CPA) at E15.5, suggesting that it remains inside the endoplasmic reticulum
(J:237614)
• beta-catenin (which binds to CDH1) is also mislocalized at E15.5
(J:237614)
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• at E16.5
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• decrease in the size and number of pancreatic acini
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• decrease in the size and number of pancreatic acini
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• altered distribution pattern of endocrine cells at E13.5 - E18.5
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• fail to form
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• alpha and beta cells remain scattered throughout the pancreas rather than migrating to form the islets of Langerhans
• no defects are seen in pre-patterning, branching morphogenesis or pancreatic progenitor fate assignment
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• decrease in the volume of the dorsal and ventral pancreas
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• degeneration of the nasal glands at E18.5
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• apoptosis of secretory tissues in the in pancreas, salivary gland, and gastric glands in the developing embryo
• apoptosis starts after cells start to synthesize large amounts of secretory cargo
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| N |
• embryos do not exhibit collagen secretion defects at E11.5
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• at 4 to 8 h after birth under nonsuckling conditions
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| N |
• no significant differences in red blood cell count, hemoglobin, or hematocrit levels in neonates
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• grape-like clusters are absent and there is no discernible islet structure
|
|
• a few cells show distended ER at E13.5 and most cells have grossly distended ER at E16.5
(J:186391)
• E-cadherin (CDH1) is mislocalized to the cytoplasm of acinar cells at E11.5 and largely co-localizes with carboxylpeptidase A (CPA) at E15.5, suggesting that it remains inside the endoplasmic reticulum
(J:237614)
• beta-catenin (which binds to CDH1) is also mislocalized at E15.5
(J:237614)
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• at E16.5
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• decrease in the size and number of pancreatic acini
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• decrease in the size and number of pancreatic acini
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• degeneration of the glands in the intestines at E18.5
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• disruption of the structures of the serous and mucous acini of salivary glands
(J:186391)
• E-cadherin and beta-catenin are mislocalized in the salivary glands at E15.5
(J:237614)
|
|
• serous acini contain grossly dilated ER and only a small percentage of acini contain secretory granules
|
|
• mucous acini contain grossly dilated ER and lack secretory granules
|
|
• degeneration of the salivary glands at E18.5
|
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• degeneration of gastric glands
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• degeneration of the glands in the stomach at E18.5
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• accumulation of proamylase and other exocrine proteins in the ER
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• degeneration of the nasal glands at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in transplantation experiments, hematopoietic stem cells transplanted into irradiated mice fail to induce a congenital dyserythropoietic anemia type II (CDAII) phenotype in recipient mice
• in transplantation experiments, fetal liver cells exhibit normal capacity to reconstitute erythropoiesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile with no detectable phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no embryos are identified at E11.5
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• only 5.6% (versus expected 12.5%) of embryos are observed at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no embryos are identified at E9.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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