Phenotypes associated with this allele

• Allele Symbol: Tet2^{Gt(AN0709)Wtsi}
• Allele Name: gene trap AN0709, Wellcome Trust Sanger Institute
• Allele ID: MGI:4345275
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tet2^Gt(AN0709)Wtsi/Tet2^Gt(AN0709)Wtsi	B6.129P2-Tet2^Gt(AN0709)Wtsi	MGI:5141271
ht2	Tet2^Gt(AN0709)Wtsi/Tet2^+	B6.129P2-Tet2^Gt(AN0709)Wtsi	MGI:5141272

Genotype
MGI:5141271

hm1

• Allelic Composition: Tet2^{Gt(AN0709)Wtsi}/Tet2^{Gt(AN0709)Wtsi}
• Genetic Background: B6.129P2-Tet2^{Gt(AN0709)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174052 )

• some aged mice develop a lethal phenotype

hematopoietic system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

abnormal common myeloid progenitor cell morphology ( J:174052 )

• mice exhibit increased common myeloid progenitors (CMP) and megakaryocyte-erythrocyte progenitors (MEP) compared with control mice

• mice exhibit reduced numbers of granulocyte-macrophage progenitor cells compared with control mice

decreased pro-B cell number ( J:174052 )

• in the bone marrow

extramedullary hematopoiesis ( J:174052 )

anemia ( J:174052 )

• in some aged mice

increased erythroid progenitor cell number ( J:174052 )

• some aged mice exhibit erythroid lineage hyperplasia with abnormal myelononocytic differentiation compared with wild-type mice

decreased erythrocyte cell number ( J:174052 )

• at 4 months and in some aged mice

thrombocytopenia ( J:174052 )

• at 4 months and in some aged mice

decreased pre-B cell number ( J:174052 )

• in the bone marrow

increased leukocyte cell number ( J:174052 )

• modest at 4 months and in some aged mice

increased double-negative T cell number ( J:174052 )

• in the thymus

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

increased B cell number ( J:174052 )

• in the spleen

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells in the peripheral blood and spleen compared with control mice

increased hematopoietic stem cell number ( J:174052 )

• mice exhibit a slight increase in the absolute number of CD150+CD48- LSK cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

liver/biliary system

enlarged liver ( J:174052 )

• at 4 months and massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

growth/size/body

weight loss ( J:174052 )

• in some aged mice

enlarged liver ( J:174052 )

• at 4 months and massive in some aged mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

immune system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

decreased pro-B cell number ( J:174052 )

• in the bone marrow

decreased pre-B cell number ( J:174052 )

• in the bone marrow

increased leukocyte cell number ( J:174052 )

• modest at 4 months and in some aged mice

increased double-negative T cell number ( J:174052 )

• in the thymus

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

increased B cell number ( J:174052 )

• in the spleen

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells in the peripheral blood and spleen compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

cellular

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

endocrine/exocrine glands

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

Genotype
MGI:5141272

ht2

• Allelic Composition: Tet2^{Gt(AN0709)Wtsi}/Tet2⁺
• Genetic Background: B6.129P2-Tet2^{Gt(AN0709)Wtsi}

mortality/aging

premature death ( J:174052 )

• some aged mice develop a lethal phenotype

hematopoietic system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

anemia ( J:174052 )

• in some aged mice

increased erythroid progenitor cell number ( J:174052 )

• some aged mice exhibit erythroid lineage hyperplasia with abnormal myelononocytic differentiation compared with wild-type mice

decreased erythrocyte cell number ( J:174052 )

• in some aged mice

thrombocytopenia ( J:174052 )

• in some aged mice

increased leukocyte cell number ( J:174052 )

• in some aged mice

increased B cell number ( J:174052 )

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• massive in some aged mice

liver/biliary system

enlarged liver ( J:174052 )

• massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

liver fibrosis ( J:174052 )

• moderate in some aged mice

growth/size/body

weight loss ( J:174052 )

• in some aged mice

enlarged liver ( J:174052 )

• massive in some aged mice

enlarged spleen ( J:174052 )

• massive in some aged mice

immune system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

increased leukocyte cell number ( J:174052 )

• in some aged mice

increased B cell number ( J:174052 )

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

cellular

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice