Phenotypes associated with this allele

• Allele Symbol: Cop1^{Gt(XR0653)Wtsi}
• Allele Name: gene trap XR0653, Wellcome Trust Sanger Institute
• Allele ID: MGI:4344899
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cop1^Gt(XR0653)Wtsi/Cop1^Gt(XR0653)Wtsi	involves: 129P2/OlaHsd	MGI:5301608
ht2	Cop1^Gt(XR0653)Wtsi/Cop1^Gt(XR0653)1.1Wtsi	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5301609

Genotype
MGI:5301608

hm1

• Allelic Composition: Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:178271 )

• no live embryos at E12.5

• E10.5 embryos smaller than littermates and developmentally retarded

cardiovascular system

abnormal heart development ( J:178271 )

• heart malformed at E9.5

Genotype
MGI:5301609

ht2

• Allelic Composition: Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:178271 )

• most die by E15.5

hematopoietic system

anemia ( J:178271 )

• develops after E12.5

homeostasis/metabolism

hydrops fetalis ( J:178271 )

• develops after E12.5