Phenotypes associated with this allele

• Allele Symbol: Kars1^{Gt(AJ0130)Wtsi}
• Allele Name: gene trap AJ0130, Wellcome Trust Sanger Institute
• Allele ID: MGI:4344829
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kars1^Gt(AJ0130)Wtsi/Kars1^Gt(AJ0130)Wtsi	involves: 129P2/OlaHsd	MGI:6472857
cx2	Kars1^Gt(AJ0130)Wtsi/Kars1^+ Tg(MMTV-PyVT)634Mul/0	involves: 129P2/OlaHsd * FVB/N	MGI:6472861

Genotype
MGI:6472857

hm1

• Allelic Composition: Kars1^{Gt(AJ0130)Wtsi}/Kars1^{Gt(AJ0130)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:264950 )

• no viable homozygous embryos are observed up to E9.5

Genotype
MGI:6472861

cx2

• Allelic Composition: Kars1^{Gt(AJ0130)Wtsi}/Kars1⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

neoplasm

decreased metastatic potential ( J:264950 )

♀ • mice exhibit a lower incidence of lung metastasis than control mice carrying the transgene on a wild-type background, as determined by counting metastatic lung nodules in female mice at 16 or 18 weeks of age