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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shmt1Gt(AD0236)Wtsi
gene trap AD0236, Wellcome Trust Sanger Institute
MGI:4344587
Summary 4 genotypes


Genotype
MGI:5426848
hm1
Allelic
Composition		 Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Genetic
Background		 B6.129P2-Shmt1Gt(AD0236)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1Gt(AD0236)Wtsi mutation (0 available); any Shmt1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:183477 )
N
• mice are born at the expected Mendelian frequency




Genotype
MGI:5426849
cx2
Allelic
Composition		 ApcMin/Apc+
Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Genetic
Background		 B6.Cg-Shmt1Gt(AD0236)Wtsi ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Shmt1Gt(AD0236)Wtsi mutation (0 available); any Shmt1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:183477 )
N
• mice exhibit the same tumorigenesis as ApcMin heterozygotes




Genotype
MGI:5426850
cx3
Allelic
Composition		 Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Tg(IGL-MYC)3Hm/0
Genetic
Background		 B6.Cg-Shmt1Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1Gt(AD0236)Wtsi mutation (0 available); any Shmt1 mutation (43 available)
Tg(IGL-MYC)3Hm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor growth/size ( J:183477 )
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice




Genotype
MGI:5426852
cx4
Allelic
Composition		 Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1Gt(AD0236)Wtsi mutation (0 available); any Shmt1 mutation (43 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:183477 )
N
• mice exhibit the same tumorigenesis as Trp53tm1Brd




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory