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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sesn2Gt(W077E06)Wrst
gene trap W077E06, German Gene Trap Consortium
MGI:4333988
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst B6.129S2-Sesn2Gt(W077E06)Wrst MGI:4458339
cx2
 		Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst 		involves: 129S2/SvPas * C57BL/6 MGI:4458341


Genotype
MGI:4458339
hm1
Allelic
Composition		 Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst
Genetic
Background		 B6.129S2-Sesn2Gt(W077E06)Wrst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sesn2Gt(W077E06)Wrst mutation (0 available); any Sesn2 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to hydrogen peroxide ( J:160854 )
• after exposure to hydrogen peroxide, mouse lung fibroblasts exhibit increased levels of reactive oxygen species compared with similarly treated wild-type cells
increased fibroblast apoptosis ( J:160854 )
• in mouse lung fibroblasts
decreased lung fibroblast proliferation ( J:160854 )
• in mouse lung fibroblasts




Genotype
MGI:4458341
cx2
Allelic
Composition		 Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbp4Gt(U3Cre)1Vmel mutation (1 available); any Ltbp4 mutation (120 available)
Sesn2Gt(W077E06)Wrst mutation (0 available); any Sesn2 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:160854 )
N
• unlike Ltbp4Gt(U3Cre)1Vmel homozygotes, lung compliance and elastin fiber morphology are not different from in wild-type mice
overexpanded pulmonary alveolus ( J:160854 )
• mice exhibit a less severe parenchymal lesions with decreased alveolar size and lung enlargement compared with Ltbp4Gt(U3Cre)1Vmel homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory