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Ltbp4Gt(U3Cre)1Vmel
Gene trapped Allele Detail
Summary
Symbol: Ltbp4Gt(U3Cre)1Vmel
Name: latent transforming growth factor beta binding protein 4; gene trap 1, Harald von Melchner
MGI ID: MGI:2388061
Synonyms: 3C7, Ltbp4S-
Gene: Ltbp4  Location: Chr7:27004561-27037117 bp, - strand  Genetic Position: Chr7, 15.87 cM
Alliance: Ltbp4Gt(U3Cre)1Vmel page
Mutation
origin
Mutant Cell Line:  3C7
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector Type: gene trap
 
Mutation detailsA retroviral gene trap vector, containing cre recombinase and U3 sequences, integrated into intron 5 in a reverse transcriptional orientation. A 98% reduction in mRNA levels was identified in homozygous mutant mice by Northern blot analysis. Western blot analysis results were correlative. The insertion of the vector is thought to interfere with the splicing of this gene. (J:47007, J:78819)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 18 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ltbp4Gt(U3Cre)1Vmel
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltbp4 Mutation:  120 strains or lines available
References
Original:  J:78819 Sterner-Kock A, et al., Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev. 2002 Sep 1;16(17):2264-73
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory