Phenotypes associated with this allele

• Allele Symbol: Sh3pxd2a^{Gt(OST445753)Lex}
• Allele Name: gene trap OST445753, Lexicon Genetics
• Allele ID: MGI:4319893
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3pxd2a^Gt(OST445753)Lex/Sh3pxd2a^Gt(OST445753)Lex	B6J.129S5-Sh3pxd2a^Gt(OST445753)Lex	MGI:5750061
hm2	Sh3pxd2a^Gt(OST445753)Lex/Sh3pxd2a^Gt(OST445753)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5750059
cx3	Sh3pxd2a^Gt(OST445753)Lex/Sh3pxd2a^Gt(OST445753)Lex Sh3pxd2b^Gt(GST_1527_E5)Lex/Sh3pxd2b^Gt(GST_1527_E5)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5750062

Genotype
MGI:5750061

hm1

• Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex}
• Genetic Background: B6J.129S5-Sh3pxd2a^{Gt(OST445753)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:219236 )

• 10% of homozygotes die shortly after the neonatal period and have a normal palate

neonatal lethality, incomplete penetrance ( J:219236 )

• 90% of mice die neonatally and have a cleft palate

craniofacial

cleft secondary palate ( J:219236 )

• homozygous mice that die in the neonatal period have a cleft palate

digestive/alimentary system

cleft secondary palate ( J:219236 )

• homozygous mice that die in the neonatal period have a cleft palate

growth/size/body

cleft secondary palate ( J:219236 )

• homozygous mice that die in the neonatal period have a cleft palate

Genotype
MGI:5750059

hm2

• Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

mortality/aging

mortality/aging ( J:219236 )

N • 20% of homozygotes survive weaning and display no phenotypic defects

preweaning lethality, incomplete penetrance ( J:219236 )

• 30% of homozygotes die between 1 day of age and weaning

• mice have no obvious defect but eventually fail to thrive and then die

perinatal lethality, incomplete penetrance ( J:219236 )

• 50% of homozygotes die within 24 hours of birth

behavior/neurological

absent gastric milk in neonates ( J:219236 )

• mice dying in the neonatal period have no milk in their stomach

craniofacial

cleft secondary palate ( J:219236 )

• mice dying in the neonatal period have a completely cleft secondary palate

skeleton

split xiphoid process ( J:219236 )

• sporadic bifid xiphisternum in mice dying in the neonatal period

digestive/alimentary system

cleft secondary palate ( J:219236 )

• mice dying in the neonatal period have a completely cleft secondary palate

growth/size/body

cleft secondary palate ( J:219236 )

• mice dying in the neonatal period have a completely cleft secondary palate

Genotype
MGI:5750062

cx3

• Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex}; Sh3pxd2b^{Gt(GST_1527_E5)Lex}/Sh3pxd2b^{Gt(GST_1527_E5)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

mortality/aging

prenatal lethality, complete penetrance ( J:219236 )

• double homozygotes die before birth but after implantation

• survival improves with one out of four wild type alleles but is still less than expected