Phenotypes associated with this allele

• Allele Symbol: Tpp2^{Gt(OST432061)Lex}
• Allele Name: gene trap OST432061, Lexicon Genetics
• Allele ID: MGI:4315077
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpp2^Gt(OST432061)Lex/Tpp2^Gt(OST432061)Lex	B6.129S5-Tpp2^Gt(OST432061)Lex	MGI:4430830
hm2	Tpp2^Gt(OST432061)Lex/Tpp2^Gt(OST432061)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:4430831

Genotype
MGI:4430830

hm1

• Allelic Composition: Tpp2^{Gt(OST432061)Lex}/Tpp2^{Gt(OST432061)Lex}
• Genetic Background: B6.129S5-Tpp2^{Gt(OST432061)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal level of surface class I molecules ( J:157195 )

• MHC class I levels on thymocytes and splenic lymphocytes are increased

• expression levels of H-2K^b are elevated on bone marrow cells cultured for 6 days and treated with type I IFN inducer, poly(I:C)

• expression levels of H-2D^b are elevated on CD4+ and CD8+ splenocytes 24 hours after mice are injected with poly(I:C)

hematopoietic system

hematopoietic system phenotype ( J:157195 )

N • unlike in targeted null Tpp2 mice, no signs of splenomegaly or extramedullary hematopoiesis are seen

Genotype
MGI:4430831

hm2

• Allelic Composition: Tpp2^{Gt(OST432061)Lex}/Tpp2^{Gt(OST432061)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

immune system

abnormal antigen presentation ( J:157195 )

• processing and presentation of peptide precursors with long N-terminal extensions in mouse embryonic fibroblasts is reduced