Analysis Tools
adipose tissue
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• brown adipose tissue is enlarged with white adipose tissue-like appearance, resulting from the accumulation of lipid droplets
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homeostasis/metabolism
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• mice show severe cold sensitivity
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• mice exhibit a reduction of CO2 production (VCO2) in the steady state before exercise and during treadmill exercise
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• oxygen consumption rates dependent on complex I, complex II and complex IV are impaired in MEFs
• mice exhibit lower oxygen consumption (VO2) in the steady state before exercise and during treadmill exercise
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• mice exhibit a higher respiration quotient during treadmill exercise
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• respiration quotient is higher during treadmill exercise, indicating a decrease in metabolic rate and a metabolic shift to glucose consumption
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• mice show 70% of the running capacity in the forced treadmill test
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• cytochrome c oxidase (COX) activity is reduced in MEFs
• COX activity is reduced in quadriceps femoris muscles at 4 months of age
• COX activities in quadriceps femoris, gastrocnemius, and cardiac muscles are 15-30% reduced
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behavior/neurological
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• mice show 70% of the running capacity in the forced treadmill test
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muscle
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• weights of quadriceps femoris muscles are reduced at 4 months of age
• however, body weights are not different
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cellular
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• reduction in mitochondrial oxidative capacity
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• mitochondrial ATP production rate is reduced in MEFs
• cellular ATP production is reduced in MEFs
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limbs/digits/tail
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• weights of quadriceps femoris muscles are reduced at 4 months of age
• however, body weights are not different
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