Phenotypes associated with this allele

• Allele Symbol: Cyp2c23^{Gt(OST85045)Lex}
• Allele Name: gene trap OST85045, Lexicon Genetics
• Allele ID: MGI:4178127
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp2c23^Gt(OST85045)Lex/Cyp2c23^Gt(OST85045)Lex	129-Cyp2c23^Gt(OST85045)Lex	MGI:5559332

Genotype
MGI:5559332

hm1

• Allelic Composition: Cyp2c23^{Gt(OST85045)Lex}/Cyp2c23^{Gt(OST85045)Lex}
• Genetic Background: 129-Cyp2c23^{Gt(OST85045)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung endothelial cell physiology ( J:207597 )

• primary pulmonary endothelial cells show reduced tubulogenic capacity in the absence or presence of added arachidonic acid

• the epoxygenase 11,12-epoxyeicosatrienoic acid metabolite restores the tubulogenic capacity of primary pulmonary endothelial cells

• VEGF fails to stimulate the tubulogenesis of primary pulmonary endothelial cells in culture as it does in wild-type cells

decreased lung endothelial cell proliferation ( J:207597 )

• primary pulmonary endothelial cells show reduced growth rates in culture under non-stimulated conditions

• the epoxygenase 11,12-epoxyeicosatrienoic acid metabolite restores the proliferative capacity of primary pulmonary endothelial cells

• VEGF fails to stimulate the proliferation of primary pulmonary endothelial cells in culture as it does in wild-type cells

neoplasm

decreased incidence of induced tumors ( J:207597 )

• tumor vascularization and growth are blunted in mutants injected with murine p60.5 cells compared to wild-type and treatment with Wyeth 14,643, a PPARalpha-selective ligand has no effect on tumors in mutants unlike in wild-type

cellular

decreased lung endothelial cell proliferation ( J:207597 )

• primary pulmonary endothelial cells show reduced growth rates in culture under non-stimulated conditions

• the epoxygenase 11,12-epoxyeicosatrienoic acid metabolite restores the proliferative capacity of primary pulmonary endothelial cells

• VEGF fails to stimulate the proliferation of primary pulmonary endothelial cells in culture as it does in wild-type cells

cardiovascular system

salt-sensitive hypertension ( J:204734 )

• mice fed a high potassium diet show increased systemic blood pressure

• amiloride treatment abolishes the high potassium-induced hypertension

growth/size/body

increased susceptibility to weight gain ( J:204734 )

• mutants fed a high potassium diet gain weight unlike wild-type mice which lose weight

homeostasis/metabolism

decreased circulating aldosterone level ( J:204734 )

• the increase in plasma aldosterone levels induced by a high potassium diet in wild-type mice is smaller in mutants

increased circulating sodium level ( J:204734 )

• mice fed a high potassium diet show increased plasma sodium concentration

decreased urine sodium level ( J:204734 )

• mice fed a high potassium diet show decreased 24-hour urinary sodium excretion

• however potassium excretion is normal in mice fed a high potassium diet

renal/urinary system

decreased urine sodium level ( J:204734 )

• mice fed a high potassium diet show decreased 24-hour urinary sodium excretion

• however potassium excretion is normal in mice fed a high potassium diet

abnormal kidney physiology ( J:204734 )

• high potassium intake fails to increase 11,12-epoxyeicosatrienoic acid formation in the cortical collecting ducts as it does in wild-type mice

• mice do not show an increase in whole-cell amiloride-sensitive sodium currents in principal cells of cortical collecting ducts in response to N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide, an inhibitor of CYP epoxygenase, as is seen in wild-type cells