Phenotypes associated with this allele

• Allele Symbol: Mthfs^{Gt(RRK291)Byg}
• Allele Name: gene trap RRK291, BayGenomics
• Allele ID: MGI:4130253
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mthfs^Gt(RRK291)Byg/Mthfs^Gt(RRK291)Byg	B6.129P2-Mthfs^Gt(RRK291)Byg	MGI:5430743
ht2	Mthfs^Gt(RRK291)Byg/Mthfs^+	B6.129P2-Mthfs^Gt(RRK291)Byg	MGI:5430744
cx3	Apc^Min/Apc^+ Mthfs^Gt(RRK291)Byg/Mthfs^+	B6.Cg-Mthfs^Gt(RRK291)Byg Apc^Min	MGI:5430745

Genotype
MGI:5430743

hm1

• Allelic Composition: Mthfs^{Gt(RRK291)Byg}/Mthfs^{Gt(RRK291)Byg}
• Genetic Background: B6.129P2-Mthfs^{Gt(RRK291)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:185874 )

• die before E9.5, even with maternal dietary purine supplementation

Genotype
MGI:5430744

ht2

• Allelic Composition: Mthfs^{Gt(RRK291)Byg}/Mthfs⁺
• Genetic Background: B6.129P2-Mthfs^{Gt(RRK291)Byg}

homeostasis/metabolism

abnormal folic acid level ( J:185874 )

• decreased folate levels in the plasma in mice on a normal chow diet compared to diet matched controls

abnormal enzyme/coenzyme activity ( J:185874 )

• decrease in de novo purine synthesis

behavior/neurological

behavior/neurological phenotype ( J:185874 )

N • no difference in food intake

growth/size/body

growth/size/body region phenotype ( J:185874 )

N • no difference in weight gain

Genotype
MGI:5430745

cx3

• Allelic Composition: Apc^Min/Apc⁺; Mthfs^{Gt(RRK291)Byg}/Mthfs⁺
• Genetic Background: B6.Cg-Mthfs^{Gt(RRK291)Byg} Apc^Min

neoplasm

neoplasm ( J:185874 )

N • small intestine and colon tumor incidence is similar to mice heterozygous for Apc^Min alone