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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet1Gt(RRG140)Byg
gene trap RRG140, BayGenomics
MGI:4129024
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg B6.129P2-Tet1Gt(RRG140)Byg MGI:5578324
hm2
 		Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:5924943
hm3
 		Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:5578325


Genotype
MGI:5578324
hm1
Allelic
Composition		 Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic
Background		 B6.129P2-Tet1Gt(RRG140)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1Gt(RRG140)Byg mutation (0 available); any Tet1 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:194101 , J:243754 )
• Background Sensitivity: fewer than expected mice on a congenic C57BL/6 background are born compared to no mice on a mixed background (J:194101)
• Background Sensitivity: fewer than expected mice on a congenic C57BL/6 background are born compared to no mice on a mixed background (J:243754)

reproductive system
reproductive system phenotype ( J:194101 )
N
• male mice exhibit normal gonads
decreased oocyte number ( J:194101 )
• from E16.5 to E18.5 due to apoptosis
• reduced fully grown oocytes and ovulated oocytes after hormonal stimulation
abnormal female meiosis ( J:194101 )
• oocytes fail to reach pachytene stage at E16.5 and fewer than expected reach pachytene stage at E17.5 and E18.5
• however, the percent of diplotene-stage oocyte at E18.5 is normal
abnormal synaptonemal complex ( J:194101 )
• increased unpaired synpatonemal complex at zygotene-stage oocyte
increased female germ cell apoptosis ( J:194101 )
• increased percentage of cleaved-Caspase-3 apoptotic germ cells in the ovaries at E16.5 and E18.5
increased ovary apoptosis ( J:194101 )
• increased apoptosis in the ovaries at E16.5 to E18.5
absent ovary ( J:194101 )
• ovarian agenesis in some mice that results in asymmetric ovary size
decreased litter size ( J:194101 )
• more so when homozygotes are bred

embryo
abnormal embryo development ( J:243754 )
• Background Sensitivity: two-thirds of mice on a congenic C57BL/6 background are abnormal by E9.5 compared to mice on a mixed background
• however, mice are normal at E7.5 to E8.5

growth/size/body
decreased birth body size ( J:243754 )
• some mice die by 2 to 3 weeks of birth

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:194101 )
• in pachytene and diplotene oocytes

cellular
decreased oocyte number ( J:194101 )
• from E16.5 to E18.5 due to apoptosis
• reduced fully grown oocytes and ovulated oocytes after hormonal stimulation
abnormal female meiosis ( J:194101 )
• oocytes fail to reach pachytene stage at E16.5 and fewer than expected reach pachytene stage at E17.5 and E18.5
• however, the percent of diplotene-stage oocyte at E18.5 is normal
abnormal synaptonemal complex ( J:194101 )
• increased unpaired synpatonemal complex at zygotene-stage oocyte
increased female germ cell apoptosis ( J:194101 )
• increased percentage of cleaved-Caspase-3 apoptotic germ cells in the ovaries at E16.5 and E18.5
increased ovary apoptosis ( J:194101 )
• increased apoptosis in the ovaries at E16.5 to E18.5
abnormal double-strand DNA break repair ( J:194101 )
• in pachytene and diplotene oocytes

endocrine/exocrine glands
increased ovary apoptosis ( J:194101 )
• increased apoptosis in the ovaries at E16.5 to E18.5
absent ovary ( J:194101 )
• ovarian agenesis in some mice that results in asymmetric ovary size




Genotype
MGI:5924943
hm2
Allelic
Composition		 Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1Gt(RRG140)Byg mutation (0 available); any Tet1 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:243754 )
• Background Sensitivity: unlike mice on a congenic C57BL/6 background some of whom survive beyond birth, mice on a mixed background exhibit fully penetrant lethality by the second generation of outbreeding to CD-1




Genotype
MGI:5578325
hm3
Allelic
Composition		 Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1Gt(RRG140)Byg mutation (0 available); any Tet1 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:243754 )
• Background Sensitivity: mice on a mixed background do not survive beyond E9.5 unlike mice on a congenic C57BL/6 background in which some mice survive beyond birth
embryonic lethality, complete penetrance ( J:194101 )
• Background Sensitivity: mice on a mixed background exhibit embryonic lethality unlike mice on a congenic C57BL/6 background that exhibit partial prenatal lethality

embryo
abnormal embryo development ( J:243754 )
• starting at E8.0 and all are deformed by E9.5
abnormal head fold morphology ( J:243754 )
• contorted anterior head fold at E8.5
excessive folding of visceral yolk sac ( J:243754 )
• convoluted visceral yolk sac layers at E8.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory