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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		LyarGt(RRG292)Byg
gene trap RRG292, BayGenomics
MGI:4128951
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		LyarGt(RRG292)Byg/LyarGt(RRG292)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:6191735
ht2
 		LyarGt(RRG292)Byg/Lyar+ involves: 129P2/OlaHsd * C57BL/6 MGI:6191736
cx3
 		LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:6191737
cx4
 		LyarGt(RRG292)Byg/Lyar+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:6191738


Genotype
MGI:6191735
hm1
Allelic
Composition		 LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:263530 )
• in primary mouse embryonic fibroblasts




Genotype
MGI:6191736
ht2
Allelic
Composition		 LyarGt(RRG292)Byg/Lyar+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:263530 )
• intermediate in primary mouse embryonic fibroblasts




Genotype
MGI:6191737
cx3
Allelic
Composition		 LyarGt(RRG292)Byg/LyarGt(RRG292)Byg
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:263530 )
• the only two mice produced from breeding heterozygotes die by 8 months from thymic lymphoma
preweaning lethality, incomplete penetrance ( J:263530 )
• fewer than expected mice were recovered, motsly affecting female mice

nervous system
exencephaly ( J:263530 )
• in 11 of 18 mice at E16.5 to E18.5 mostly in female mice

neoplasm
increased T cell derived lymphoma incidence ( J:263530 )
• as in Trp53tm1Tyj homozygotes

limbs/digits/tail
curly tail ( J:263530 )
• in some mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:263530 )
• as in Trp53tm1Tyj homozygotes




Genotype
MGI:6191738
cx4
Allelic
Composition		 LyarGt(RRG292)Byg/Lyar+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LyarGt(RRG292)Byg mutation (0 available); any Lyar mutation (30 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:263530 )
• fewer than expected mice were recovered

embryo
spina bifida ( J:263530 )
• in 1 of 27 mice

nervous system
spina bifida ( J:263530 )
• in 1 of 27 mice
exencephaly ( J:263530 )
• in 7 of 27 mice at E16.5 to E18.5 mostly in female mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory