Analysis Tools
mortality/aging
|
• mice begin to die at E14.5
• no viable mice are detected at E18.5
|
hematopoietic system
|
• fetal liver cells exhibit impaired erythroblast terminal differentiation with impaired cell-cycle progression compared with wild-type mice
• impaired primitive erythropoiesis at E15.5
|
|
• reduced BFU-E and CFU-E colonies from the E12.5 fetal liver
|
|
• abnormal multilobular morphologies or butterfly shapes at E12.5 increased apoptotic erythroblasts at E12.5
• enucleated erythroblasts exhibit abnormal F-actin organization compared with wild-type cells
|
|
• starting at E12.5 in the fetal liver
|
|
• rare enucleated red blood cells at E14.5
|
liver/biliary system
|
• more abundant larger blast-type cells and fewer late-stage orthochromatophilic erythroblasts in the liver at E12.5
• defective formation of erythroblast-macrophage islands in the fetal liver
|
small liver
(
J:208725
)
|
• at E12.5
|
integument
cellular
|
• impaired cell-cycle progression in fetal liver cells during erythroblast terminal differentiation
|
