About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch2Gt(LST103)Byg
gene trap LST103, BayGenomics
MGI:4123984
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Notch2Gt(LST103)Byg/Notch2+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg 		involves: 129P2/OlaHsd MGI:4418249


Genotype
MGI:4418249
cx1
Allelic
Composition		 Notch2Gt(LST103)Byg/Notch2+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2Gt(LST103)Byg mutation (0 available); any Notch2 mutation (97 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:155893 )
• mice die shortly after birth

respiratory system
abnormal lung development ( J:155893 )
• myofibroblasts in the lungs exhibit reduced differentiation, as determined by sma+ expression, compared to in wild-type mice
impaired lung alveolus development ( J:155893 )
• 3 of 6 surviving mice exhibit altered alveolar development compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory