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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lman1Gt(XST010)Byg
gene trap XST010, BayGenomics
MGI:4123879
Summary 7 genotypes


Genotype
MGI:5296771
hm1
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 129S1.129P2-Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:177067 )
• Background Sensitivity: fewer than expected mice are present at weaning unlike on a mixed background




Genotype
MGI:5296773
hm2
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 A.129P2-Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:177067 )
N
• Background Sensitivity: mice exhibit normal survival unlike on a congenic 129S1, C57BL/6, or DBA/2 background




Genotype
MGI:6195537
hm3
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 B6.129-Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:262681 )
• fewer than expected mice are present

homeostasis/metabolism
abnormal protein level ( J:262681 )
• increased factor V and aspartate transaminase levels in the liver with retention in the ER
abnormal circulating protein level ( J:262681 )
• decreased factor V and VIII serum levels
decreased circulating aspartate transaminase level ( J:262681 )
• small decrease in male, but not female, mice with accumulation in the ER




Genotype
MGI:5296770
hm4
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 B6.129P2-Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:177067 )
• Background Sensitivity: despite normal numbers at E18.5, only one-third of expected mice are present at weaning unlike on a mixed background

cellular
cellular phenotype ( J:177067 )
N
• COPII-coated vesicle formation in mouse embryonic fibroblasts is normal
abnormal endoplasmic reticulum morphology ( J:177067 )
• slightly dilated in hepatocytes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:177067 )
N
• mice exhibit normal bleeding time




Genotype
MGI:5296772
hm5
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 D2.129P2-Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:177067 )
• Background Sensitivity: fewer than expected mice are present at weaning unlike on a mixed background




Genotype
MGI:5296774
hm6
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:177067 )
N
• Background Sensitivity: mice exhibit normal survival unlike on a congenic 129S1, C57BL/6, or DBA/2 background




Genotype
MGI:6195535
cx7
Allelic
Composition		 Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Mcfd2tm1Dgi/Mcfd2tm1Dgi
Genetic
Background		 B6.129-Mcfd2tm1Dgi Lman1Gt(XST010)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1Gt(XST010)Byg mutation (0 available); any Lman1 mutation (21 available)
Mcfd2tm1Dgi mutation (1 available); any Mcfd2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal protein level ( J:262681 )
• increased factor V and aspartate transaminase levels in the liver with retention in the ER
abnormal circulating protein level ( J:262681 )
• decreased factor V and VIII serum levels but not as much as in Mcfd2tm1Dgi homozygotes
decreased circulating aspartate transaminase level ( J:262681 )
• small decrease in male, but not female, mice with accumulation in the ER




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory