Mcfd2^tm1Dgi
Targeted Allele Detail

Summary

• Symbol: Mcfd2^tm1Dgi
• Name: multiple coagulation factor deficiency 2; targeted mutation 1, David Ginsburg
• MGI ID: MGI:5544759
• Gene: Mcfd2 Location: Chr17:87561871-87573363 bp, - strand Genetic Position: Chr17, 57.06 cM
• Alliance: Mcfd2^tm1Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262681
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 of the targeted gene were replaced with a neomycin resistance cassette via homologous recombination. (J:262681)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcfd2 Mutation: 14 strains or lines available

References

• Original: J:262681 Zhu M, et al., Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Adv. 2018 May 8;2(9):1014-1021
• All: 2 reference(s)