Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrm3Gt(IST12726F8)Tigm mutation
(0 available);
any
Srrm3 mutation
(28 available)
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mortality/aging
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• mice show decreased survival after P21, with most dying before P200
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growth/size/body
behavior/neurological
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• mice spend less time on the rotarod than wild-type mice at 1, 2, and 3 months of age
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nervous system
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• the external germinal layer of the cerebellum, which forms from granule cell precursors, persists longer than normal and is thus thicker at P16
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• most Purkinje cells degenerate between P40 and P90
• however, neurodegeneration in the cortex is not seen
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrm3Gt(IST12726F8)Tigm mutation
(0 available);
any
Srrm3 mutation
(28 available)
Srrm4bv mutation
(2 available);
any
Srrm4 mutation
(39 available)
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mortality/aging
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• mice die neonatally due to an inability to start breathing
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respiratory system
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• none of the newborn mice start to breathe and alveoli of newborns are not expanded with air
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nervous system
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• cortical neurons form functional synapses in vitro, but their spontaneous activity is abnormal, with calcium oscillations being of an abnormally high amplitude and low frequency and they are highly synchronized
• however, no anatomical defects are seen in the brain at E19
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• cortical neuron cultures treated with the GABA(A)R inhibitor gabazine show a reduction in the amplitude and an increase in the frequency of calcium oscillations, the opposite of wild-type cultures which show increased amplitude and decreased frequency of calcium oscillations
• cortical neurons are defective for the developmental switch in GABAergic neurotransmission
• cortical neuron cultures and brain slice cultures treated with the GABA(A)R agonist muscimol show increased intracellular calcium compared to wild-type cultures in which few neurons respond to muscimol
• more neurons from spinal cord slices respond to a mix of GABA and glycine with elevated intracellular calcium than in wild-type slices
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