About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rps27lGt(IST11658B7)Tigm
gene trap IST11658B7, Texas A&M Institute for Genomic Medicine
MGI:4022789
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm C57BL/6-Rps27lGt(IST11658B7)Tigm MGI:5707898
hm2
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm involves: 129 * C57BL/6N MGI:5707899
hm3
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm involves: 129S2/SvPas * C57BL/6N MGI:5707902
cx4
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6N MGI:5707900
cx5
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * C57BL/6N MGI:5707901


Genotype
MGI:5707898
hm1
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 C57BL/6-Rps27lGt(IST11658B7)Tigm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:223276 )
• Background Sensitivity: mice on a pure C57BL/6 background die within 12 days of birth while mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days

hematopoietic system
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10
decreased common myeloid progenitor cell number ( J:223276 )
• due to increased apoptosis without reduced proliferation in myeloid progenitors from E14.5 livers
decreased spleen weight ( J:223276 )
• at P8 to P10
abnormal hematopoietic stem cell physiology ( J:223276 )
• hematopoietic stem cells fail to reconstitute mice with sterilized bone marrow

growth/size/body
decreased body size ( J:223276 )
• half of wild-type
decreased body weight ( J:223276 )
• half of wild-type

liver/biliary system
small liver ( J:223276 )
• at E14.5
liver hypoplasia ( J:223276 )
• at E14.5

cellular
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments

endocrine/exocrine glands
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10

immune system
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10
decreased spleen weight ( J:223276 )
• at P8 to P10




Genotype
MGI:5707899
hm2
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:223276 )
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days while mice on a pure C57BL/6 background die within 12 days of birth
postnatal lethality, incomplete penetrance ( J:223276 )
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days while mice on a pure C57BL/6 background die within 12 days of birth

hematopoietic system

endocrine/exocrine glands

immune system




Genotype
MGI:5707902
hm3
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:223276 )
• mice survive until 5 weeks of age




Genotype
MGI:5707900
cx4
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (18 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:223276 )
N
• postnatal lethality observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued

neoplasm
increased lymphoma incidence ( J:223276 )
• 50% of mice are dying of lymphoma by 150 days as in Trp53tm1Tyj homozygotes

growth/size/body
growth/size/body region phenotype ( J:223276 )
N
• growth retardation and organ hypocellularity (spleen, thymus and bone marrow) observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued

hematopoietic system
hematopoietic system phenotype ( J:223276 )
N
• hematopoietic stem cell depletion and hematopoietic failure observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued




Genotype
MGI:5707901
cx5
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (18 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

mortality/aging
mortality/aging ( J:223276 )
N
• postnatal lethality observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued
premature death ( J:223276 )
• mice die sooner than mice with a wild-type allele of Rps271

neoplasm
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

hematopoietic system
decreased bone marrow cell number ( J:223276 )
• partially rescued

cellular
aneuploidy ( J:223276 )
• in lymphoma cells and mouse embryonic fibroblasts

growth/size/body
growth/size/body region phenotype ( J:223276 )
N
• growth retardation and organ hypocellularity (spleen, thymus and bone marrow) observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued
enlarged liver ( J:223276 )
enlarged spleen ( J:223276 )

immune system
enlarged lymph nodes ( J:223276 )
• in 1 of 14 mice

liver/biliary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory