All Phenotypes Sppl2b<Gt(Ayu21-T160)Imeg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sppl2b^{Gt(Ayu21-T160)Imeg}
gene trap Ayu21-T160, Institute of Molecular Embryology and Genetics
MGI:3923485

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sppl2b^{Gt(Ayu21-T160)Imeg}/Sppl2b^{Gt(Ayu21-T160)Imeg}	B6N.Cg-Sppl2b^{Gt(Ayu21-T160)Imeg}	MGI:5698089
cx2	Sppl2a^tm1Basc/Sppl2a^tm1Basc Sppl2b^{Gt(Ayu21-T160)Imeg}/Sppl2b^{Gt(Ayu21-T160)Imeg}	B6N.Cg-Sppl2a^tm1Basc Sppl2b^{Gt(Ayu21-T160)Imeg}	MGI:5698091

Allelic Composition	Sppl2b^{Gt(Ayu21-T160)Imeg}/Sppl2b^{Gt(Ayu21-T160)Imeg}
Genetic Background	B6N.Cg-Sppl2b^{Gt(Ayu21-T160)Imeg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2b^{Gt(Ayu21-T160)Imeg} mutation (0 available); any Sppl2b mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:213519 )

N	• viable with no overt impairments • B cell maturation and function are normal • basal immunoglobulin concentrations in plasma are normal • no reduction in CD11c+ MHC-II+ cells

Allelic Composition	Sppl2a^tm1Basc/Sppl2a^tm1Basc Sppl2b^{Gt(Ayu21-T160)Imeg}/Sppl2b^{Gt(Ayu21-T160)Imeg}
Genetic Background	B6N.Cg-Sppl2a^tm1Basc Sppl2b^{Gt(Ayu21-T160)Imeg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2a^tm1Basc mutation (0 available); any Sppl2a mutation (45 available)
Sppl2b^{Gt(Ayu21-T160)Imeg} mutation (0 available); any Sppl2b mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:213519 )

• significant reduction of total B cells in the spleen, lymph nodes, and peritoneal cavity

• B cell numbers similar to mice homozygous only for Sppl2a^tm1Basc

abnormal mature B cell morphology ( J:213519 )

• numerous endosomal vesicles as is seen in mice homozygous only for Sppl2a^tm1Basc

decreased immunoglobulin level ( J:213519 )

• levels decreased to near limit of detectability as seen in mice homozygous only for Sppl2a^tm1Basc