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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnip1Gt(E059E05)Wrst
gene trap E059E05, German Gene Trap Consortium
MGI:3894752
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst B6.129P2-Tnip1Gt(E059E05)Wrst MGI:5305969
hm2
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst involves: 129P2/OlaHsd * C57BL/6 MGI:5305972
cx3
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5305973


Genotype
MGI:5305969
hm1
Allelic
Composition
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic
Background
B6.129P2-Tnip1Gt(E059E05)Wrst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnip1Gt(E059E05)Wrst mutation (0 available); any Tnip1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: fewer than expected mice are born alive but the percent is increased compared to in mice on a mixed 129P2/OlaHsd and C57BL/6 background




Genotype
MGI:5305972
hm2
Allelic
Composition
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnip1Gt(E059E05)Wrst mutation (0 available); any Tnip1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enlarged spleen and lymph nodes in Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst mice

mortality/aging
• mice die within 4 months of birth
• fewer than expected mice are born alive
• Background Sensitivity: fewer mice are born on a mixed 129P2/OlaHsd and C57BL/6 background than on a C57BL/6 congenic background

immune system
• in the peripheral blood and spleen
• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS
• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS
• mice exhibit many characteristics of human SLE, including the appearance of immature granulocytes in the peripheral blood and development of autoreactive antibodies and glomerulonephritis
• bone marrow cells transplanted into irradiated mice develop inflammatory disease
• however, mice do not develop joint inflammation

hematopoietic system
• in the peripheral blood and spleen

growth/size/body

renal/urinary system

homeostasis/metabolism




Genotype
MGI:5305973
cx3
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
Tnip1Gt(E059E05)Wrst mutation (0 available); any Tnip1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 6 months of birth
• slightly fewer than expected mice are born alive

immune system
• mice develop similar inflammatory disease (body weight loss, anemia, neutrophilia, leukocyte organ infiltrations, and glomerulonephritis) as observed in Tnip1Gt(E059E05)Wrst homozygotes

hematopoietic system

growth/size/body

renal/urinary system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory