Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnip1Gt(E059E05)Wrst mutation
(0 available);
any
Tnip1 mutation
(55 available)
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mortality/aging
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• Background Sensitivity: fewer than expected mice are born alive but the percent is increased compared to in mice on a mixed 129P2/OlaHsd and C57BL/6 background
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnip1Gt(E059E05)Wrst mutation
(0 available);
any
Tnip1 mutation
(55 available)
|
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Enlarged spleen and lymph nodes in Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst mice
mortality/aging
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• mice die within 4 months of birth
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• fewer than expected mice are born alive
• Background Sensitivity: fewer mice are born on a mixed 129P2/OlaHsd and C57BL/6 background than on a C57BL/6 congenic background
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immune system
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• in the peripheral blood and spleen
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• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS
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• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS
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• mice exhibit many characteristics of human SLE, including the appearance of immature granulocytes in the peripheral blood and development of autoreactive antibodies and glomerulonephritis
• bone marrow cells transplanted into irradiated mice develop inflammatory disease
• however, mice do not develop joint inflammation
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hematopoietic system
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• in the peripheral blood and spleen
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growth/size/body
renal/urinary system
homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(47 available)
Tnip1Gt(E059E05)Wrst mutation
(0 available);
any
Tnip1 mutation
(55 available)
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mortality/aging
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• mice die within 6 months of birth
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• slightly fewer than expected mice are born alive
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immune system
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• mice develop similar inflammatory disease (body weight loss, anemia, neutrophilia, leukocyte organ infiltrations, and glomerulonephritis) as observed in Tnip1Gt(E059E05)Wrst homozygotes
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hematopoietic system
growth/size/body
renal/urinary system