Phenotypes associated with this allele

• Allele Symbol: Wdr48^{Gt(CSD197)Byg}
• Allele Name: gene trap CSD197, BayGenomics
• Allele ID: MGI:3877670
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr48^Gt(CSD197)Byg/Wdr48^Gt(CSD197)Byg	B6.129P2-Wdr48^Gt(CSD197)Byg	MGI:5553064
ht2	Wdr48^Gt(CSD197)Byg/Wdr48^+	B6.129P2-Wdr48^Gt(CSD197)Byg	MGI:5553065

Genotype
MGI:5553064

hm1

• Allelic Composition: Wdr48^{Gt(CSD197)Byg}/Wdr48^{Gt(CSD197)Byg}
• Genetic Background: B6.129P2-Wdr48^{Gt(CSD197)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:206106 )

• no mice are present at E10.5

embryonic lethality, incomplete penetrance ( J:206106 )

• fewer than expected mice are present at E7.5 to E8.5

embryo

embryonic growth retardation ( J:206106 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:206106 )

• at E7.5

Genotype
MGI:5553065

ht2

• Allelic Composition: Wdr48^{Gt(CSD197)Byg}/Wdr48⁺
• Genetic Background: B6.129P2-Wdr48^{Gt(CSD197)Byg}

reproductive system

decreased oocyte number ( J:206106 )

♀

decreased male germ cell number ( J:206106 )

♂

abnormal seminiferous tubule morphology ( J:206106 )

♂

small testis ( J:206106 )

♂

testicular atrophy ( J:206106 )

♂

abnormal spermatogenesis ( J:206106 )

♂ • limited

reduced female fertility ( J:206106 )

♀

reduced male fertility ( J:206106 )

♂

skeleton

abnormal skeleton morphology ( J:206106 )

• at 3.5 weeks

integument

abnormal skin physiology ( J:206106 )

• reduced epithelial growth (thickening) following topical TPA exposure compared with wild-type mice

growth/size/body

decreased birth weight ( J:206106 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:206106 )

♂

small testis ( J:206106 )

♂

testicular atrophy ( J:206106 )

♂

cellular

decreased oocyte number ( J:206106 )

♀

decreased male germ cell number ( J:206106 )

♂