All Phenotypes Kif13b<Gt(AF0005)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif13b^{Gt(AF0005)Wtsi}
gene trap AF0005, Wellcome Trust Sanger Institute
MGI:3876683

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif13b^{Gt(AF0005)Wtsi}/Kif13b^{Gt(AF0005)Wtsi}	involves: 129P2/OlaHsd * C57BL/6J	MGI:6385206
cx2	Kif13a^{Gt(AF0553)Wtsi}/Kif13a^{Gt(AF0553)Wtsi} Kif13b^{Gt(AF0005)Wtsi}/Kif13b^{Gt(AF0005)Wtsi}	involves: 129P2/OlaHsd * C57BL/6J	MGI:6385207

Allelic Composition	Kif13b^{Gt(AF0005)Wtsi}/Kif13b^{Gt(AF0005)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif13b^{Gt(AF0005)Wtsi} mutation (1 available); any Kif13b mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:282570 )

increased circulating HDL cholesterol level ( J:282570 )

• mice show relatively increased HDL levels

increased circulating LDL cholesterol level ( J:282570 )

cellular

abnormal fibroblast physiology ( J:282570 )

• MEFs show reduced uptake of LDL without disruption of hydrolysis

Allelic Composition	Kif13a^{Gt(AF0553)Wtsi}/Kif13a^{Gt(AF0553)Wtsi} Kif13b^{Gt(AF0005)Wtsi}/Kif13b^{Gt(AF0005)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif13a^{Gt(AF0553)Wtsi} mutation (0 available); any Kif13a mutation (109 available)
Kif13b^{Gt(AF0005)Wtsi} mutation (1 available); any Kif13b mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:282570 )

• high mortality after birth, with most newborn pups either dead or cannibalized and occasionally newborn pups are found dead at day 1

behavior/neurological

absent gastric milk in neonates ( J:282570 )

• pups that die at day 1 have stomachs filled with air without any milk

craniofacial

short snout ( J:282570 )

• dead pups exhibit a short nose

growth/size/body

short snout ( J:282570 )

• dead pups exhibit a short nose

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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