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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RbpmsGt(AS0009)Wtsi
gene trap AS0009, Wellcome Trust Sanger Institute
MGI:3864173
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RbpmsGt(AS0009)Wtsi/RbpmsGt(AS0009)Wtsi involves: 129P2/OlaHsd MGI:8226626
cx2
 		RbpmsGt(AS0009)Wtsi/RbpmsGt(AS0009)Wtsi
Rbpms2tm1.1Thbr/Rbpms2tm1.1Thbr 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:8226663


Genotype
MGI:8226626
hm1
Allelic
Composition		 RbpmsGt(AS0009)Wtsi/RbpmsGt(AS0009)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RbpmsGt(AS0009)Wtsi mutation (0 available); any Rbpms mutation (493 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:369747 )
• viable at birth but only ~25% are still alive at 40 weeks of age

cardiovascular system
increased binucleate cardiomyocyte number ( J:369747 )
• premature increase in the number of binucleated cardiomyocytes at P0
• greater than 2 fold increase in multi-nucleated cardiomyocyes in the adult heart
premature cardiomyocyte maturation ( J:369747 )
• premature increase in the number of binucleated cardiomyocytes at P0
increased heart atrium size ( J:369747 )
• slightly enlarged at 16 weeks of age
• however, no gross malformations are detected

digestive/alimentary system
abnormal intestine morphology ( J:369747 )
• dilation of the intestine at 25 weeks of age
abnormal intestinal smooth muscle morphology ( J:369747 )
• reduction in the smooth muscle cell layer and strong dedifferentiation of remaining smooth muscle cells at 25 weeks of age

muscle
increased binucleate cardiomyocyte number ( J:369747 )
• premature increase in the number of binucleated cardiomyocytes at P0
• greater than 2 fold increase in multi-nucleated cardiomyocyes in the adult heart
abnormal intestinal smooth muscle morphology ( J:369747 )
• reduction in the smooth muscle cell layer and strong dedifferentiation of remaining smooth muscle cells at 25 weeks of age




Genotype
MGI:8226663
cx2
Allelic
Composition		 RbpmsGt(AS0009)Wtsi/RbpmsGt(AS0009)Wtsi
Rbpms2tm1.1Thbr/Rbpms2tm1.1Thbr
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpms2tm1.1Thbr mutation (0 available); any Rbpms2 mutation (202 available)
RbpmsGt(AS0009)Wtsi mutation (0 available); any Rbpms mutation (493 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:369747 )
• die between E11.5 and E13.5

cardiovascular system
abnormal heart morphology ( J:369747 )
• severe heart defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory