Analysis Tools
mortality/aging
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• 27% of newborn mice are dead or in severe respiratory distress within 4 to 6 hours of birth unlike wild-type mice
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respiratory system
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• in some mice exhibiting respiratory distress
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• some mice with respiratory distress exhibit collapsed airspaces, hemorrhagic regions, and accumulation of proteinaceous material in distal airways unlike wild-type mice
• however, mice exhibit normal number, size, and morphology of lamellar bodies in alveolar type II cells
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atelectasis
(
J:161467
)
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• in some mice exhibiting respiratory distress
|
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• 27% of newborn mice are dead or in severe respiratory distress within 4 to 6 hours of birth unlike wild-type mice
|
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• surfactant isolated from mice that die shortly after birth fails to reduce minimum surface tension resulting in a 2.9-fold increase in surface tension unlike wild-type surfactant
• however, mice exhibit normal surfactant production
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homeostasis/metabolism
cardiovascular system
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• in some mice exhibiting respiratory distress
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