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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmtm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:3851145
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmtm1Shzh/Atmtm2.1Fwa involves: 129S6/SvEvTac MGI:5463806
cn2
 		Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129 * 129S6/SvEvTac MGI:5463807
cn3
 		Atmtm2.1Fwa/Atmtm2.1Fwa
Tg(VAV1-cre)1Graf/0 		involves: 129S6/SvEvTac MGI:6771725


Genotype
MGI:5463806
cn1
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• embryonic stem cells infected with a cre-expressing adenovirus exhibit increased genomic instability (breaks in one or both sister chromatids) compared with wild-type and Atmtm1Fwa cells




Genotype
MGI:5463807
cn2
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

immune system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

hematopoietic system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells




Genotype
MGI:6771725
cn3
Allelic
Composition		 Atmtm2.1Fwa/Atmtm2.1Fwa
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers
increased T cell derived lymphoma incidence ( J:277750 )
• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)

hematopoietic system
decreased B cell number ( J:277750 )
• the percentage of peripheral B cells is decreased
decreased T cell number ( J:277750 )
• the percentage of peripheral T cells is decreased
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers

immune system
decreased B cell number ( J:277750 )
• the percentage of peripheral B cells is decreased
decreased T cell number ( J:277750 )
• the percentage of peripheral T cells is decreased
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers

neoplasm
increased T cell derived lymphoma incidence ( J:277750 )
• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory