About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmtm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:3851145
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmtm1Shzh/Atmtm2.1Fwa involves: 129S6/SvEvTac MGI:5463806
cn2
 		Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129 * 129S6/SvEvTac MGI:5463807
cn3
 		Atmtm2.1Fwa/Atmtm2.1Fwa
Tg(VAV1-cre)1Graf/0 		involves: 129S6/SvEvTac MGI:6771725


Genotype
MGI:5463806
cn1
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• embryonic stem cells infected with a cre-expressing adenovirus exhibit increased genomic instability (breaks in one or both sister chromatids) compared with wild-type and Atmtm1Fwa cells




Genotype
MGI:5463807
cn2
Allelic
Composition		 Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Shzh mutation (0 available); any Atm mutation (169 available)
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (945 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

immune system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells

hematopoietic system
abnormal class switch recombination ( J:191288 )
• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atmtm1Fwa cells




Genotype
MGI:6771725
cn3
Allelic
Composition		 Atmtm2.1Fwa/Atmtm2.1Fwa
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2.1Fwa mutation (2 available); any Atm mutation (169 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers
increased T cell derived lymphoma incidence ( J:277750 )
• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)

hematopoietic system
decreased B cell number ( J:277750 )
• the percentage of peripheral B cells is decreased
decreased T cell number ( J:277750 )
• the percentage of peripheral T cells is decreased
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers

immune system
decreased B cell number ( J:277750 )
• the percentage of peripheral B cells is decreased
decreased T cell number ( J:277750 )
• the percentage of peripheral T cells is decreased
decreased thymocyte number ( J:277750 )
• the cellularity of the thymus is decreased, with decreased thymocyte numbers

neoplasm
increased T cell derived lymphoma incidence ( J:277750 )
• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory