Phenotypes associated with this allele

• Allele Symbol: Atm^tm2.1Fwa
• Allele Name: targeted mutation 2.1, Frederick W Alt
• Allele ID: MGI:3851145
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atm^tm1Shzh/Atm^tm2.1Fwa	involves: 129S6/SvEvTac	MGI:5463806
cn2	Atm^tm1Shzh/Atm^tm2.1Fwa Gt(ROSA)26Sor^tm1(cre/ERT2)Thl/Gt(ROSA)26Sor^+	involves: 129 * 129S6/SvEvTac	MGI:5463807
cn3	Atm^tm2.1Fwa/Atm^tm2.1Fwa Tg(VAV1-cre)1Graf/0	involves: 129S6/SvEvTac	MGI:6771725

Genotype
MGI:5463806

cn1

• Allelic Composition: Atm^tm1Shzh/Atm^tm2.1Fwa
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

chromosomal instability ( J:191288 )

• embryonic stem cells infected with a cre-expressing adenovirus exhibit increased genomic instability (breaks in one or both sister chromatids) compared with wild-type and Atm^tm1Fwa cells

Genotype
MGI:5463807

cn2

• Allelic Composition: Atm^tm1Shzh/Atm^tm2.1Fwa; Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S6/SvEvTac

cellular

chromosomal instability ( J:191288 )

• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atm^tm1Fwa cells

immune system

abnormal class switch recombination ( J:191288 )

• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atm^tm1Fwa cells

hematopoietic system

abnormal class switch recombination ( J:191288 )

• B cells from tamoxifen-treated mice exhibit reduced class switch recombination with increased genomic instability (especially chromatid breaks) compared with wild-type cells but at the same level as in Atm^tm1Fwa cells

Genotype
MGI:6771725

cn3

• Allelic Composition: Atm^tm2.1Fwa/Atm^tm2.1Fwa; Tg(VAV1-cre)1Graf/0
• Genetic Background: involves: 129S6/SvEvTac

endocrine/exocrine glands

decreased thymocyte number ( J:277750 )

• the cellularity of the thymus is decreased, with decreased thymocyte numbers

increased T cell derived lymphoma incidence ( J:277750 )

• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)

hematopoietic system

increased T cell derived lymphoma incidence ( J:277750 )

• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)

decreased B cell number ( J:277750 )

• the percentage of peripheral B cells is decreased

decreased T cell number ( J:277750 )

• the percentage of peripheral T cells is decreased

decreased thymocyte number ( J:277750 )

• the cellularity of the thymus is decreased, with decreased thymocyte numbers

immune system

increased T cell derived lymphoma incidence ( J:277750 )

• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)

decreased B cell number ( J:277750 )

• the percentage of peripheral B cells is decreased

decreased T cell number ( J:277750 )

• the percentage of peripheral T cells is decreased

decreased thymocyte number ( J:277750 )

• the cellularity of the thymus is decreased, with decreased thymocyte numbers

neoplasm

increased T cell derived lymphoma incidence ( J:277750 )

• mice develop thymic lymphomas; tumors exhibit a relatively immature phenotype (CD3low CD4+ CD8+)