Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation
(0 available);
any
Cnp mutation
(26 available)
Myrftm1Barr mutation
(1 available);
any
Myrf mutation
(100 available)
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mortality/aging
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• mice die during third postnatal week
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behavior/neurological
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• severe tremors are observed
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• seizures develop postnatally
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nervous system
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• seizures develop postnatally
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• 2-fold higher levels of apoptotic cells (having blebbed processes, fragmented nuclei) are observed in premyelinating oligodendrocytes compared to controls; transition from premyelinating to mature oligodendrocytes is blocked when assayed at P7
• postmitotic oligodendrocytes are generated but then undergo apoptosis
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• severe loss of myelin is observed in spinal cord at P16, but spinal roots are myelinated
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• severe loss of myelination in CNS white matter tracts is observed at P16
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mortality/aging
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• mice die during third postnatal week
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behavior/neurological
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• severe tremors are observed around P11
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nervous system
N |
• gross CNS architecture is normal
• motor neuron population in spinal cord is intact
• peripheral nerves are fully myelinated
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• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated
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• severe loss of myelin basic protein (immunostaining) is observed in spinal cord at P13, but spinal root myelination (myelinated by Schwann cells) is normal
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• essentially complete loss of myelination in CNS white matter tracts is observed at P13
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vision/eye
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• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myrftm1Barr mutation
(1 available);
any
Myrf mutation
(100 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
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vision/eye
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• by P22, especially overlying depigmented areas
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• especially overlying depigmented areas
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• patchy loss of pigmentation as early as E15.5
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• especially overlying depigmented areas
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• reduced peak flicker amplitude
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• reduced a- and b-wave amplitudes
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nervous system
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• by P22, especially overlying depigmented areas
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• especially overlying depigmented areas
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pigmentation
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• patchy loss of pigmentation as early as E15.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myrftm1Barr mutation
(1 available);
any
Myrf mutation
(100 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
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vision/eye
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• late onset; less severe than in mice homozygous for the conditional allele
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pigmentation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myrftm1.1Barr mutation
(0 available);
any
Myrf mutation
(100 available)
Myrftm1Barr mutation
(1 available);
any
Myrf mutation
(100 available)
Tg(rx3-icre)1Mjam mutation
(0 available)
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pigmentation
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• patchy loss of pigmentation
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vision/eye
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• patchy loss of pigmentation
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