Myrf^tm1.1Barr
Targeted Allele Detail

Summary

• Symbol: Myrf^tm1.1Barr
• Name: myelin regulatory factor; targeted mutation 1.1, Ben Barres
• MGI ID: MGI:6383116
• Gene: Myrf Location: Chr19:10185636-10218112 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Myrf^tm1.1Barr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275842
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 8 was floxed. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 8. (J:275842)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myrf Mutation: 100 strains or lines available

References

• Original: J:275842 Garnai SJ, et al., Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice. PLoS Genet. 2019 May;15(5):e1008130
• All: 1 reference(s)