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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfngtm1Seco
targeted mutation 1, Susan E Cole
MGI:3849429
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfngtm1Seco/Mfngtm1Seco involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:3849430
cx2
 		Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Seco/Mfngtm1Seco 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ MGI:3849431
cx3
 		Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Seco/Mfngtm1Seco
Rfngtm1Tfv/Rfngtm1Tfv 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ MGI:3849432


Genotype
MGI:3849430
hm1
Allelic
Composition		 Mfngtm1Seco/Mfngtm1Seco
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfngtm1Seco mutation (1 available); any Mfng mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:149312 )
• viable and fertile with no gross abnormalities




Genotype
MGI:3849431
cx2
Allelic
Composition		 Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Seco/Mfngtm1Seco
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfngtm1Seco mutation (1 available); any Mfng mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:149312 )
• fewer than expected are found at weaning however survivors are viable and fertile
postnatal lethality, incomplete penetrance ( J:149312 )
• fewer than expected are found at weaning
• reduction in numbers found at weaning is not greater than that of Lfngtm1Rjo single homozygous littermates

skeleton
abnormal skeleton morphology ( J:149312 )
• skeleton phenotype is not significantly different from that of Lfngtm1Rjo single homozygous mice

limbs/digits/tail




Genotype
MGI:3849432
cx3
Allelic
Composition		 Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Seco/Mfngtm1Seco
Rfngtm1Tfv/Rfngtm1Tfv
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfngtm1Seco mutation (1 available); any Mfng mutation (33 available)
Rfngtm1Tfv mutation (0 available); any Rfng mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:149312 )
• fewer than expected are found at weaning however survivors are viable and fertile
postnatal lethality, incomplete penetrance ( J:149312 )
• fewer than expected are found at weaning
• reduction in numbers found at weaning is not greater than that of Lfngtm1Rjo single homozygous littermates

skeleton
abnormal skeleton morphology ( J:149312 )
• skeleton phenotype is not significantly different from that of Lfngtm1Rjo single homozygous mice

limbs/digits/tail
limbs/digits/tail phenotype ( J:149312 )
N
• unlike in chick embryo experiments, no limb abnormalities are seen




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory